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<section id="title-slide" class="quarto-title-block center">
<h1 class="title">Neurologisk JC</h1>
<p class="subtitle">Temporal Trends in Vascular Risk Factor Burden Among Young Adults With Ischemic Stroke</p>
<div class="quarto-title-authors">
</div>
</section>
<section id="background" class="slide level2">
<h2>Background</h2>
<ul>
<li>Stroke is a leading cause of death and disability<br>
</li>
<li>Traditionally considered a disease of older adults<br>
</li>
<li>Rising stroke incidence among <strong>young adults (18–55 years old)</strong><br>
</li>
<li>Increasing <strong>vascular risk factors (VRFs)</strong> may be driving this trend<br>
</li>
<li>Study aims to analyze <strong>temporal trends in VRF burden</strong> among young stroke patients</li>
</ul>
</section>
<section id="study-design-data-source" class="slide level2">
<h2>Study Design &amp; Data Source</h2>
<ul>
<li><strong>Prospective Cohort Study</strong> using <strong>Florida Stroke Registry (FSR)</strong><br>
</li>
<li>Data collected from <strong>2014–2022</strong> across <strong>172 hospitals</strong><br>
</li>
<li><strong>Inclusion Criteria:</strong>
<ul>
<li>Patients <strong>18–55 years old</strong> with <strong>ischemic stroke (IS)</strong><br>
</li>
</ul></li>
<li><strong>Exclusion Criteria:</strong>
<ul>
<li>Patients outside age range<br>
</li>
<li>Patients with <strong>TIA, intracranial hemorrhage, or subarachnoid hemorrhage</strong></li>
</ul></li>
</ul>
</section>
<section id="data-collection-variables" class="slide level2">
<h2>Data Collection &amp; Variables</h2>
<ul>
<li>Data obtained from <strong>Get With The Guidelines-Stroke (GWTG-S)</strong><br>
</li>
<li><strong>Demographics:</strong>
<ul>
<li>Age, sex, race/ethnicity<br>
</li>
</ul></li>
<li><strong>Vascular Risk Factors (VRFs):</strong>
<ul>
<li>Hypertension, dyslipidemia, obesity, diabetes, smoking<br>
</li>
<li>Atrial fibrillation, coronary artery disease, heart failure, sleep apnea<br>
</li>
</ul></li>
<li><strong>Polymorbidity:</strong> Defined as <strong>3 or more VRFs</strong></li>
</ul>
</section>
<section id="statistical-analysis" class="slide level2">
<h2>Statistical Analysis</h2>
<ul>
<li><strong>Comparative Analysis:</strong>
<ul>
<li>Continuous variables: <strong>t-test / Wilcoxon-Mann-Whitney</strong><br>
</li>
<li>Categorical variables: <strong>Chi-square test</strong><br>
</li>
</ul></li>
<li><strong>Temporal Trends Analysis:</strong>
<ul>
<li>VRF trends assessed across study period</li>
</ul></li>
</ul>
</section>
<section id="main-results" class="slide level2">
<h2>Main Results</h2>
<ul>
<li><strong>Total patients analyzed:</strong> 36,488<br>
</li>
<li><strong>Age breakdown:</strong>
<ul>
<li>18–35 years: <strong>3,363 patients (9.2%)</strong><br>
</li>
<li>36–55 years: <strong>33,125 patients (90.8%)</strong></li>
</ul></li>
</ul>
</section>
<section id="section" class="slide level2">
<h2></h2>
<ul>
<li><strong>Key Findings:</strong>
<ul>
<li><strong>Polymorbidity (≥3 VRFs) increased</strong> over time:
<ul>
<li><strong>18–35 years:</strong> 10.9% → 16.4% (p = 0.002)<br>
</li>
<li><strong>36–55 years:</strong> 34.6% → 41.9% (p &lt; 0.001)<br>
</li>
</ul></li>
<li><strong>Higher VRF burden in</strong>:
<ul>
<li><strong>Non-Hispanic Black</strong> patients</li>
<li><strong>Male</strong> patients<br>
</li>
</ul></li>
<li><strong>Most common VRFs:</strong> Hypertension, obesity, diabetes</li>
</ul></li>
</ul>
</section>
<section id="strengths-of-the-study" class="slide level2">
<h2>Strengths of the Study</h2>
<p>✅ <strong>Large, diverse cohort</strong> from a statewide registry<br>
✅ <strong>Standardized data collection</strong> via GWTG-S<br>
✅ <strong>Analyzed temporal trends</strong> in VRFs<br>
✅ <strong>Examined racial &amp; sex disparities</strong> in VRF burden</p>
</section>
<section id="study-limitations" class="slide level2">
<h2>Study Limitations</h2>
<p>❌ <strong>Limited generalizability</strong> (Florida hospitals only)<br>
❌ <strong>No stroke etiology data</strong> (high missingness)<br>
❌ <strong>Unknown VRF severity &amp; management</strong> (no treatment data)<br>
❌ <strong>Potential bias in VRF reporting</strong> (better diagnosis over time)<br>
❌ <strong>Lack of socioeconomic data</strong> (income, education, access to care)</p>
</section>
<section id="conclusion" class="slide level2">
<h2>Conclusion</h2>
<ul>
<li><strong>VRF burden is increasing</strong> in young adults with stroke<br>
</li>
<li><strong>Disparities exist</strong>—higher polymorbidity in <strong>Black and male patients</strong><br>
</li>
<li><strong>Early identification &amp; prevention strategies</strong> are crucial<br>
</li>
<li><strong>Future research</strong> should focus on <strong>stroke etiology &amp; socioeconomic factors</strong></li>
</ul>
</section>
</div>
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