87 lines
2.9 KiB
Text
87 lines
2.9 KiB
Text
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---
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title: "Neurologisk JC"
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subtitle: "Temporal Trends in Vascular Risk Factor Burden Among Young Adults With Ischemic Stroke"
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format:
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revealjs:
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theme: serif
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---
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## Background
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- Stroke is a leading cause of death and disability
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- Traditionally considered a disease of older adults
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- Rising stroke incidence among **young adults (18–55 years old)**
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- Increasing **vascular risk factors (VRFs)** may be driving this trend
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- Study aims to analyze **temporal trends in VRF burden** among young stroke patients
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## Study Design & Data Source
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- **Prospective Cohort Study** using **Florida Stroke Registry (FSR)**
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- Data collected from **2014–2022** across **172 hospitals**
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- **Inclusion Criteria:**
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- Patients **18–55 years old** with **ischemic stroke (IS)**
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- **Exclusion Criteria:**
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- Patients outside age range
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- Patients with **TIA, intracranial hemorrhage, or subarachnoid hemorrhage**
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## Data Collection & Variables
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- Data obtained from **Get With The Guidelines-Stroke (GWTG-S)**
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- **Demographics:**
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- Age, sex, race/ethnicity
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- **Vascular Risk Factors (VRFs):**
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- Hypertension, dyslipidemia, obesity, diabetes, smoking
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- Atrial fibrillation, coronary artery disease, heart failure, sleep apnea
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- **Polymorbidity:** Defined as **3 or more VRFs**
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## Statistical Analysis
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- **Comparative Analysis:**
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- Continuous variables: **t-test / Wilcoxon-Mann-Whitney**
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- Categorical variables: **Chi-square test**
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- **Temporal Trends Analysis:**
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- VRF trends assessed across study period
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## Main Results
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- **Total patients analyzed:** 36,488
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- **Age breakdown:**
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- 18–35 years: **3,363 patients (9.2%)**
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- 36–55 years: **33,125 patients (90.8%)**
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##
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- **Key Findings:**
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- **Polymorbidity (≥3 VRFs) increased** over time:
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- **18–35 years:** 10.9% → 16.4% (p = 0.002)
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- **36–55 years:** 34.6% → 41.9% (p < 0.001)
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- **Higher VRF burden in**:
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- **Non-Hispanic Black** patients
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- **Male** patients
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- **Most common VRFs:** Hypertension, obesity, diabetes
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## Strengths of the Study
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✅ **Large, diverse cohort** from a statewide registry
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✅ **Standardized data collection** via GWTG-S
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✅ **Analyzed temporal trends** in VRFs
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✅ **Examined racial & sex disparities** in VRF burden
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## Study Limitations
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❌ **Limited generalizability** (Florida hospitals only)
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❌ **No stroke etiology data** (high missingness)
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❌ **Unknown VRF severity & management** (no treatment data)
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❌ **Potential bias in VRF reporting** (better diagnosis over time)
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❌ **Lack of socioeconomic data** (income, education, access to care)
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## Conclusion
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- **VRF burden is increasing** in young adults with stroke
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- **Disparities exist**—higher polymorbidity in **Black and male patients**
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- **Early identification & prevention strategies** are crucial
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- **Future research** should focus on **stroke etiology & socioeconomic factors**
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